Endocrine Abstracts

Introduction: Maternally inherited diabetes and deafness (MIDD), is a rare entity. Most commonly, it is related to a point mutation in the mitochondrial DNA (mtDNA) at position 3243 (m.3243A>G) encoding the gene for tRNA. A high index of suspicion is required for the diagnosis due to a wide heterogeneity in its clinical presentation which reflects different levels of mutated mtDNA among mitochondria in a given tissue (heteroplasmy). Thyroid cancer risk has never been speci...

Introduction: Adrenal myelolipomas are benign and fatty tumors usually detected incidentally in imaging tests. Their prevalence increases in patients with CAH, probably because corticosteroid deficiency causes high ACTH levels that stimulate adrenal growth, although their effect on the growth of adrenal tumors is not yet well established.Clinical case: A 41-year-old man with classic 21 OH deficiency, losing salt since he was 10 months old,with stable dos...

Introduction and objective: Treatment with integrated continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring systems (CGM) helps to improve glycaemic control in people with type 1 diabetes mellitus (DM1). There is increasing use in pregnant women, but there are no protocols for its continuation during delivery. The aim of this work is to analyse glycaemic control during pregnancy, in addition to studying obstetric and neonatal outcomes.<p class="...

Introduction: Pregnancy involves distinct metabolic stages, initially characterized by maternal anabolism, followed by a catabolic phase driven by placental lactogen and various cytokines, leading to varying degrees of insulin resistance. DM is the most common metabolic disorder linked to pregnancy.Objective: The study aimed to detail the clinical characteristics, obstetric complications, and neonatal outcomes of patients with GDM and their children....

Introduction: T2DM is associated with an increased risk of fractures. This heightened risk is attributed to factors such as prolonged disease duration and chronic glycemic control. Interestingly, despite this increased fracture risk, patients with T2DM often exhibit normal or even elevated BMD compared to non-diabetic individuals. This phenomenon is thought to be a result of reduced bone remodeling, coupled with changes in bone microarchitecture.Objectiv...

Objective: Analysis of referrals from Primary Care to the Endocrinology Department for analytical findings of elevated prolactin levels and their subsequent management after initial assessment.Material and methods: Retrospective descriptive study of 118 patients who were referred to the Endocrinology and Nutrition department of the Dos Hermanas Peripheral Specialities Centre between October 2020 and December 2022. Patients already diagnosed with hyperpro...

Introduction: Intracranial Idiopathic Hypertension (IIH) is a rare complication of testosterone therapy. It is usually benign, but may result and permanent blindness. Its diagnosis is based on a high CSF (> 25 cm H2O) pressure, in the absence of specific causes. The androgen receptor is expressed in the human choroid plexus, and may enhance the activity of Na+/K+-ATPase, and therefore CSF secretion.Methods: Review of the patient’s cli...

Introduction: The 48XXXY karyotype is an infrequent (incidence about 1/50000 male births) sporadic aneuploidy of the sex chromosomes, classically considered as a variant of the Klinefelter syndrome (47XXY). Although many of their characteristics are shared, patients with the 48XXXY karyotype suffer from additional endocrinological and neuropsychological disturbances which are not part of the classic Klinefelter syndrome. Hereby we present a clinical case.<p class="abstext"...

Introduction: Oral semaglutide has been available in the Spanish market since November 2021. This new formulation has broken the self-injection barrier, and may enhance patient satisfaction.Methods: Retrospective review of the patients′ records and presential or telephonic interviews. All patients expressed their consent for the anonymous processing of their data. Numeric data are given as mean + s.d; paired t-test was used for comparison. Satisfac...

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...